Thrombopoiesis-stimulating proteins having reduced immunogenicity

The present invention relates to variant thrombopoietin proteins that possess thrombopoiesis-stimulating activity and have reduced immunogenicity. In particular, variants of thrombopoietin with reduced ability to bind one or more human class II MHC molecules are described.

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Bibliographische Detailangaben
Hauptverfasser: CHIRINO ARTHUR J, YAZAL JAMAL EL, VIELMETTER JOST, MARSHALL SHANNON ALICIA, MCDONNELL PETER
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to variant thrombopoietin proteins that possess thrombopoiesis-stimulating activity and have reduced immunogenicity. In particular, variants of thrombopoietin with reduced ability to bind one or more human class II MHC molecules are described.