Asymmetric catalytic hydrogenation process for preparation of chiral cyclic beta-aminoesters

Asymmetric catalytic hydrogenation process for preparation of chiral cyclic beta-aminoesters

A novel process for the asymmetric synthesis of substituted cyclic beta-amino-carboxylates of the type shown in the specification from appropriate beta-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors.

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Bibliographische Detailangaben
Hauptverfasser: MCLEOD DOUGLAS D, YUE TAI-YUEN, DEERBERG JOERG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A novel process for the asymmetric synthesis of substituted cyclic beta-amino-carboxylates of the type shown in the specification from appropriate beta-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors.