Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade

Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade

The present invention relates to prodrug compounds, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.

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Bibliographische Detailangaben
Hauptverfasser: NEUMANN WILLIAM L, RUEPPEL MELVIN L, CASE BRENDA, WEBBER RONALD K, LONG SCOTT, MOORMANN ALAN E, GARLAND DANNY J, ZENG QINGPING, PARLOW JOHN J, HAYES MICHAEL J, SNYDER JEFFERY S, SOUTH MICHAEL S, HUANG HORNGIH, TRUJILLO JOHN, JONES DARIN E, HUANG WEI, TOTH MIHALY V, SCHOLTEN JEFFREY A
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to prodrug compounds, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.