Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercho...

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Bibliographische Detailangaben
Hauptverfasser: LAMBERT LLL MILLARD HURST, CADILLA RODOLFO, BANKER PIERETTE, RAFFERTY STEPHEN WILLIAM, STERNBACH DANIEL DAVID, SZNAIDMAN MARCOS LUIS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.