Morpholin-acetamide derivatives for the treatment of inflammatory diseases
Compounds of formula (I) wherein: R represents C1-16 alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y -, aryl-Y -, heteroaryl-Y -, aryl-(O)t-aryl-Y -, aryl-(O)t-heteroaryl-Y -, heteroaryl-(O)t-aryl-Y -, heteroaryl-(O)t-heteroaryl-Y -, C2-6 alkenyl-Y -, aryl-O-Y -, heteroaryl-O-Y -, C1-16 alkyl-SO2-Y -...
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| creator | ANCLIFF RACHAEL ANNE HARRISON LEE ANDREW KEELING SUZANNE ELAINE HODGSON SIMON TEANBY COOK CAROLINE MARY ELDRED COLIN DAVID GORE PAUL MARTIN LEWELL XIAO QING JUDD DUNCAN BRUCE ROBERTSON GRAEME MICHAEL SWANSON STEPHEN |
| description | Compounds of formula (I) wherein: R represents C1-16 alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y -, aryl-Y -, heteroaryl-Y -, aryl-(O)t-aryl-Y -, aryl-(O)t-heteroaryl-Y -, heteroaryl-(O)t-aryl-Y -, heteroaryl-(O)t-heteroaryl-Y -, C2-6 alkenyl-Y -, aryl-O-Y -, heteroaryl-O-Y -, C1-16 alkyl-SO2-Y -,M-Y -,J -Y -, -CN or C3-8 cycloalkyl-Y - or C3-8 cycloalkenyl-Y -, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C1-16 Alkyl groups; R represents hydrogen or C1-16 alkyl; X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or Calkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R and R independently represent hydrogen or C1-14 alkyl; Z represents a bond, CO, SO2, CR R (CH2)n, (CH2)nCR R , CHR (CH2)nO, CHR (CH2)nS, CHR (CH2)nOCO, CHR (CH2 |
| format | Patent |
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HARRISON LEE ANDREW ; KEELING SUZANNE ELAINE ; HODGSON SIMON TEANBY ; COOK CAROLINE MARY ; ELDRED COLIN DAVID ; GORE PAUL MARTIN ; LEWELL XIAO QING ; JUDD DUNCAN BRUCE ; ROBERTSON GRAEME MICHAEL ; SWANSON STEPHEN</creatorcontrib><description>Compounds of formula (I) wherein: R represents C1-16 alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y -, aryl-Y -, heteroaryl-Y -, aryl-(O)t-aryl-Y -, aryl-(O)t-heteroaryl-Y -, heteroaryl-(O)t-aryl-Y -, heteroaryl-(O)t-heteroaryl-Y -, C2-6 alkenyl-Y -, aryl-O-Y -, heteroaryl-O-Y -, C1-16 alkyl-SO2-Y -,M-Y -,J -Y -, -CN or C3-8 cycloalkyl-Y - or C3-8 cycloalkenyl-Y -, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C1-16 Alkyl groups; R represents hydrogen or C1-16 alkyl; X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or C<1-14 >alkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R and R independently represent hydrogen or C1-14 alkyl; Z represents a bond, CO, SO2, CR R (CH2)n, (CH2)nCR R , CHR (CH2)nO, CHR (CH2)nS, CHR (CH2)nOCO, CHR (CH2</subsc</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040325&DB=EPODOC&CC=US&NR=2004058923A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040325&DB=EPODOC&CC=US&NR=2004058923A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ANCLIFF RACHAEL ANNE</creatorcontrib><creatorcontrib>HARRISON LEE ANDREW</creatorcontrib><creatorcontrib>KEELING SUZANNE ELAINE</creatorcontrib><creatorcontrib>HODGSON SIMON TEANBY</creatorcontrib><creatorcontrib>COOK CAROLINE MARY</creatorcontrib><creatorcontrib>ELDRED COLIN DAVID</creatorcontrib><creatorcontrib>GORE PAUL MARTIN</creatorcontrib><creatorcontrib>LEWELL XIAO QING</creatorcontrib><creatorcontrib>JUDD DUNCAN BRUCE</creatorcontrib><creatorcontrib>ROBERTSON GRAEME MICHAEL</creatorcontrib><creatorcontrib>SWANSON STEPHEN</creatorcontrib><title>Morpholin-acetamide derivatives for the treatment of inflammatory diseases</title><description>Compounds of formula (I) wherein: R represents C1-16 alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y -, aryl-Y -, heteroaryl-Y -, aryl-(O)t-aryl-Y -, aryl-(O)t-heteroaryl-Y -, heteroaryl-(O)t-aryl-Y -, heteroaryl-(O)t-heteroaryl-Y -, C2-6 alkenyl-Y -, aryl-O-Y -, heteroaryl-O-Y -, C1-16 alkyl-SO2-Y -,M-Y -,J -Y -, -CN or C3-8 cycloalkyl-Y - or C3-8 cycloalkenyl-Y -, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C1-16 Alkyl groups; R represents hydrogen or C1-16 alkyl; X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or C<1-14 >alkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R and R independently represent hydrogen or C1-14 alkyl; Z represents a bond, CO, SO2, CR R (CH2)n, (CH2)nCR R , CHR (CH2)nO, CHR (CH2)nS, CHR (CH2)nOCO, CHR (CH2</subsc</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzL0KwjAUhuEsDqLewwHnQmwV6iiiiOCkzuVgvtBA_kgOBe9eBy_A6V0e3rm63lLJY_IuNvyCcHAGZFDcxOImVLKpkIwgKWAJiELJkovWcwgsqbzJuAquqEs1s-wrVr8u1Pp8ehwvDXIaUPP3HyHD895qvdW7ft92h033n_oAVjo2xA</recordid><startdate>20040325</startdate><enddate>20040325</enddate><creator>ANCLIFF RACHAEL ANNE</creator><creator>HARRISON LEE ANDREW</creator><creator>KEELING SUZANNE ELAINE</creator><creator>HODGSON SIMON TEANBY</creator><creator>COOK CAROLINE MARY</creator><creator>ELDRED COLIN DAVID</creator><creator>GORE PAUL MARTIN</creator><creator>LEWELL XIAO QING</creator><creator>JUDD DUNCAN BRUCE</creator><creator>ROBERTSON GRAEME MICHAEL</creator><creator>SWANSON STEPHEN</creator><scope>EVB</scope></search><sort><creationdate>20040325</creationdate><title>Morpholin-acetamide derivatives for the treatment of inflammatory diseases</title><author>ANCLIFF RACHAEL ANNE ; HARRISON LEE ANDREW ; KEELING SUZANNE ELAINE ; HODGSON SIMON TEANBY ; COOK CAROLINE MARY ; ELDRED COLIN DAVID ; GORE PAUL MARTIN ; LEWELL XIAO QING ; JUDD DUNCAN BRUCE ; ROBERTSON GRAEME MICHAEL ; SWANSON STEPHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2004058923A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ANCLIFF RACHAEL ANNE</creatorcontrib><creatorcontrib>HARRISON LEE ANDREW</creatorcontrib><creatorcontrib>KEELING SUZANNE ELAINE</creatorcontrib><creatorcontrib>HODGSON SIMON TEANBY</creatorcontrib><creatorcontrib>COOK CAROLINE MARY</creatorcontrib><creatorcontrib>ELDRED COLIN DAVID</creatorcontrib><creatorcontrib>GORE PAUL MARTIN</creatorcontrib><creatorcontrib>LEWELL XIAO QING</creatorcontrib><creatorcontrib>JUDD DUNCAN BRUCE</creatorcontrib><creatorcontrib>ROBERTSON GRAEME MICHAEL</creatorcontrib><creatorcontrib>SWANSON STEPHEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANCLIFF RACHAEL ANNE</au><au>HARRISON LEE ANDREW</au><au>KEELING SUZANNE ELAINE</au><au>HODGSON SIMON TEANBY</au><au>COOK CAROLINE MARY</au><au>ELDRED COLIN DAVID</au><au>GORE PAUL MARTIN</au><au>LEWELL XIAO QING</au><au>JUDD DUNCAN BRUCE</au><au>ROBERTSON GRAEME MICHAEL</au><au>SWANSON STEPHEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Morpholin-acetamide derivatives for the treatment of inflammatory diseases</title><date>2004-03-25</date><risdate>2004</risdate><abstract>Compounds of formula (I) wherein: R represents C1-16 alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y -, aryl-Y -, heteroaryl-Y -, aryl-(O)t-aryl-Y -, aryl-(O)t-heteroaryl-Y -, heteroaryl-(O)t-aryl-Y -, heteroaryl-(O)t-heteroaryl-Y -, C2-6 alkenyl-Y -, aryl-O-Y -, heteroaryl-O-Y -, C1-16 alkyl-SO2-Y -,M-Y -,J -Y -, -CN or C3-8 cycloalkyl-Y - or C3-8 cycloalkenyl-Y -, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C1-16 Alkyl groups; R represents hydrogen or C1-16 alkyl; X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or C<1-14 >alkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R and R independently represent hydrogen or C1-14 alkyl; Z represents a bond, CO, SO2, CR R (CH2)n, (CH2)nCR R , CHR (CH2)nO, CHR (CH2)nS, CHR (CH2)nOCO, CHR (CH2</subsc</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
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