Phthalazinone derivatives

Phthalazinone derivatives

A compound of formula: or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; R is a C5-7 aryl group substituted in the meta position by the group R , and optionally further substituted; wherein R...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SMITH GRAEME CAMERON MURRAY, COCKCROFT XIAO-LING, DIXON LESLEY, MARTIN NIALL MORRISON BARR, HOARE JANET, EVERSLEY PENNY JANE, KERRIGAN FRANK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound of formula: or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; R is a C5-7 aryl group substituted in the meta position by the group R , and optionally further substituted; wherein R is selected from: and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.