Hybrid transgenic mouse with accelerated onsent of Alzheimer type amyloid plaques in brain

The invention provides a transgenic rodent whose genome comprises a mutant hAPP transgene and an hAChE transgene. Methods and materials for making such transgenic rodents, and using them to identify agents that affect the progression of Alzheimer's disease are also provided.

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Bibliographische Detailangaben
Hauptverfasser:	BRIMIJOIN WILLIAM STEPHEN, SOREQ HERMONA, YOUNKIN STEVEN G, REES TINA
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a transgenic rodent whose genome comprises a mutant hAPP transgene and an hAChE transgene. Methods and materials for making such transgenic rodents, and using them to identify agents that affect the progression of Alzheimer's disease are also provided.