Asymmetric synthesis of amino-pyrrolidinones

Asymmetric synthesis of amino-pyrrolidinones

A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described. These compounds are useful as intermediates for MMP and TACE inhibitors.

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Bibliographische Detailangaben
Hauptverfasser: CAMPAGNA SILVIO, CONFALONE PASQUALE N, SAVAGE SCOTT A, YATES MATTHEW, WALTERMIRE ROBERT E, MAGNUS NICHOLAS A, MELONI DAVID J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described. These compounds are useful as intermediates for MMP and TACE inhibitors.