Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis

Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis

Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as m...

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Hauptverfasser: REEL JON K, FOLMER BEVERLY K, DROSTE JAMES J, BRITTON THOMAS C, AUDIA JAMES E, WU JING, MABRY THOMAS E, TUNG JAY S, PORTER WARREN J, THORSETT EUGENE D, SCOTT WILLIAM LEONARD, LATIMER LEE H, EID CLARK NORMAN, NISSEN JEFFREY S, JOHN VARGHESE, HUFFMAN GEORGE W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.