Malathion carboxylesterase

The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethylol organophosphates. The DNA molecule comprises a nucleotide sequence havin...

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Bibliographische Detailangaben
Hauptverfasser:	BOYCE THOMAS MARK, RUSSELL ROBYN JOYCE, NEWCOMB RICHARD DAVID, CAMPBELL PETER MALCOLM, ROBIN GEOFFREY CHARLES DE QUETTEVILLE, CLAUDIANOS CHARLES, BROWNLIE JEREMY COLIN, SMYTH KERRIE-ANN, OAKESHOTT JOHN GRAHAM
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING ORPROTECTING AGAINST HARMFUL CHEMICAL AGENTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FIRE-FIGHTING HUMAN NECESSITIES LIFE-SAVING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethylol organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc?E 7, in which the protein encoded by the DNA molecule differs from E 3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.