Novel lipoglycopeptide antibiotics

Provided are novel lipoglycopeptides exhibiting bacterial signal peptidase inhibitory activity. Also provided are actinomycete strains that produce these lipoglycopeptides, methods of producing such lipoglycopeptides by culturing these strains, pharmaceutical compositions comprising these lipoglycop...

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Bibliographische Detailangaben
Hauptverfasser: BELVO MATTHEW DAVID, PENG SHENG-BIN, KULANTHAIVEL PALANIAPPAN, SMITKA TIM ALLEN, KREUZMAN ADAM JOSEPH
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided are novel lipoglycopeptides exhibiting bacterial signal peptidase inhibitory activity. Also provided are actinomycete strains that produce these lipoglycopeptides, methods of producing such lipoglycopeptides by culturing these strains, pharmaceutical compositions comprising these lipoglycopeptides, and methods of treating bacterial infections comprising contacting bacteria susceptible to treatment with the present bacterial signal peptidase inhibitor lipoglycopeptides. These lipoglycopeptides are useful in human and veterinary medicine.