3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same

Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammati...

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Hauptverfasser: MAVANDADI FARAH, WATERBURY L. DAVID, DANIELZADEH ALBERT, WILCOX ALLAN L, CARNEY JOHN M
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.