Devices and methods for high throughput patch clamp assays

A device for measuring electrophysiological properties of a cell membrane of an individual cell comprises a plate provided with at least one opening. The opening is bounded by a surface and the surface is modified, such as via heat treatment, to facilitate formation of a gigaseal. A chamber is adjac...

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Bibliographische Detailangaben
Hauptverfasser:	MATTHEAKIS LARRY C, NG KERWIN C. K, SAVTCHENKO ALEXEI N, KEDAR HAIM, KELLY ANDREW J.G
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A device for measuring electrophysiological properties of a cell membrane of an individual cell comprises a plate provided with at least one opening. The opening is bounded by a surface and the surface is modified, such as via heat treatment, to facilitate formation of a gigaseal. A chamber is adjacent to the plate. The chamber is in fluid communication with at least one opening and is adapted to hold an electrically conductive solution. The plate further comprises a first electrode located in the chamber and a second electrode located adjacent to the plate.