Constrained helical peptides and methods of making same

Constrained helical peptides and methods of making same

Provided are cyclized peptides with a constrained region(s) having an alpha-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such...

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Bibliographische Detailangaben
Hauptverfasser: BRAISTED ANDREW C, STAROVASNIK MELISSA A, PHELAN J. CHRISTOPHER, WELLS JAMES A, JUDICE J. KEVIN, MCDOWELL ROBERT S
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Provided are cyclized peptides with a constrained region(s) having an alpha-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.