Method for removing a universal linker from an oligonucleotide

The invention relates to a method for cleavage of a linker from an oligonucleotide comprising contacting an oligonucleotide-linker conjugate with a gaseous nucleophilic cleavage reagent under conditions that result in the cleavage of the linker from the oligonucleotide.

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Bibliographische Detailangaben
Hauptverfasser:	PIRES RICHARD M, GEBEYEHU GULILAT
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a method for cleavage of a linker from an oligonucleotide comprising contacting an oligonucleotide-linker conjugate with a gaseous nucleophilic cleavage reagent under conditions that result in the cleavage of the linker from the oligonucleotide.