Immunoglobulin binding protein

The present invention is directed to an immunoglobulin light chain binding protein which comprises the amino acid sequence of SEQ ID NO:1 modified by an amino acid substitution at one or more of positions 39, 53 and 57 and/or by an amino acid insertion between positions 59 and 60 such that the disso...

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Bibliographische Detailangaben
Hauptverfasser:	GORE MICHAEL GRAHAM, ROBERTS SIAN ELERI, BECKINGHAM JENNIFER ANN
Format:	Patent
Sprache:	eng
Schlagworte:	ADVERTISING AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CRYPTOGRAPHY CULTURE MEDIA DISPLAY DISPLAYING EDUCATION ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING LABELS OR NAME-PLATES METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SEALS SIGNS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to an immunoglobulin light chain binding protein which comprises the amino acid sequence of SEQ ID NO:1 modified by an amino acid substitution at one or more of positions 39, 53 and 57 and/or by an amino acid insertion between positions 59 and 60 such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin kappa-chain is 400 nM or more at pH 8, or the amino acid sequence of a corresponding immunoglobulin light chain binding domain modified by an amino acid substitution at one or more of the positions equivalent to positions 39, 53 and 57 of SEQ ID NO:1 and/or by an amino acid insertion between positions equivalent to positions 59 and 60 of SEQ ID NO:1, such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin kappa-chain is 400 nM or more at pH 8, or the amino acid sequence of a fragment of (a) or (b) which contains at least one said substitution and/or insertion, such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin kappa-chain is 400 nM or more at pH 8.