Novel combination of benzoquinazoline antifolates and protecting agents

The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic...

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Hauptverfasser: DUCH DAVID STANLEY, KOCH ARTHUR, FERONE ROBERT, SMITH GARY KEITH
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.