Methods for preparation of bioprosthetic tissue and implantable devices comprising such bioprosthetic tissue

The present invention provides methods of inactivating and removing infectious agents from tissues of use in bioprosthetic devices. The methods include the removal and blockage of binding sites on the tissues for the infectious agents. Also provided are methods for blocking a site on an infectious a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LOSHBAUGH CHRISTINE, CUNANAN CRYSTAL M, HELMUS MICHAEL N, SARNER H. CHRIS, DINH TAN THANH, CABILING CHRISTINE M
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Beschreibung
Zusammenfassung:	The present invention provides methods of inactivating and removing infectious agents from tissues of use in bioprosthetic devices. The methods include the removal and blockage of binding sites on the tissues for the infectious agents. Also provided are methods for blocking a site on an infectious agent that binds to a site on the tissue. The invention also provides a method for preventing or reducing the calcification of a bioprosthetic tissue. The method includes removing or blocking a phospholipid calcium nucleation site from the tissue.