Smart biochip arrays and systems and methods for using the same

A smart biochip array comprises an array of test sites disposed on a substrate and a smart circuit operatively associated with the substrate. Each test site contains a distinct type of probe molecule, and the smart circuit includes a memory that stores data identifying which distinct type of molecule is stored in each test site. The test sites in the biochip array are exposed to a sample that may contain target molecules capable of binding with probe molecules contained in one or more test sites. A system for scanning the exposed smart biochip array includes a detector for detecting binding between probe molecules and target molecules in each test site and a reader for reading data from the smart circuit, including data identifying the type of probe molecules contained in each test site.