NUCLEIC ACIDS FOR REDUCING CARBOHYDRATE EPITOPES

The invention relates to nucleic acids which encode a first glycosyltransferase which competes with a second enzyme for a substrate, thereby reducing the formation of a product of the second enzyme. The nucleic acids are useful in producing cells and organs with reduced antigenicity and which may be...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCKENZIE IAN CAMPBELL FARQUHAR, SANDRIN MAURO SERGIO
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to nucleic acids which encode a first glycosyltransferase which competes with a second enzyme for a substrate, thereby reducing the formation of a product of the second enzyme. The nucleic acids are useful in producing cells and organs with reduced antigenicity and which may be used for transplantation.