PCIe TLP size and alignment management

A data storage device includes a memory device and a controller coupled to the memory device. The controller is configured to issue an unaligned transaction, determine that there is a transfer failure indication for the unaligned transaction, and retry the unaligned transaction with either a different alignment or a different transfer size. The different alignment or the different transfer size is used for another unaligned transaction from a same address range upon successful retry of the unaligned transaction.