Isoform-selective TGFB1 inhibitors and use thereof

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

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Bibliographische Detailangaben
Hauptverfasser:	Capili, Allan, Stein, Caitlin, Buckler, Alan, Lin, Susan, Avery, Andrew, Chapron, Christopher, Martin, Constance, Dagbay, Kevin B, Littlefield, Christopher, Carven, Gregory J, Wawersik, Stefan, Datta, Abhishek, Schurpf, Thomas, Cooper, Anthony, Salotto, Matthew, Jackson, Justin W
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.