Information handling system mouse power management

An information handling system mouse includes a position sensor that detects movement and a push button that detects button press inputs for communication to an information handling system. The position sensor detects positions with a high sensitivity having a higher power consumption or a low sensitivity having a lower sensitivity. The push button detects button press inputs with a high scan rate having a higher power consumption or a low scan rate having a lower power consumption. The mouse configures to plural high and low power consumption modes based upon a detected usage pattern and/or a command from an information handling system, such as to adapt the mouse to use by different applications executing on the information handling system.