Benzimidazolone derived inhibitors of BCL6

Benzimidazolone derived inhibitors of BCL6

The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Davis, Owen Alexander, Lloyd, Matthew Garth, Hoelder, Swen, Woodward, Hannah, Innocenti, Paolo, Bellenie, Benjamin Richard, Cheung, Kwai Ming Jack, Varela Rodriguez, Ana, Carter, Michael K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.