Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins

Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disord...

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Hauptverfasser:	Karra, Srinivasa, Sprott, Kevin Tyler, Wiles, Jason Allan, Chen, Jesse Jingyang, Saulnier, Mark George, Ray, Soumya
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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creator	Karra, Srinivasa Sprott, Kevin Tyler Wiles, Jason Allan Chen, Jesse Jingyang Saulnier, Mark George Ray, Soumya
description	Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.
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subjects	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
title	Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins
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