Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins

Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins

Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disord...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Karra, Srinivasa, Sprott, Kevin Tyler, Wiles, Jason Allan, Chen, Jesse Jingyang, Saulnier, Mark George, Ray, Soumya
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.