TLR9 inhibitors to suppress inflammatory response to pathogens

TLR9 inhibitors to suppress inflammatory response to pathogens

This invention relates generally to the field of medicine, and particularly to a TLR-9-specific inhibitor peptide effective in vitro and in vivo for modification of inflammatory signaling and host defense pathways. This peptide can be used for TLR-targeting pharmaceutics for treating inflammatory re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Toshchakov, Vladimir, Javmen, Artur
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention relates generally to the field of medicine, and particularly to a TLR-9-specific inhibitor peptide effective in vitro and in vivo for modification of inflammatory signaling and host defense pathways. This peptide can be used for TLR-targeting pharmaceutics for treating inflammatory responses caused by various pathogenic and infectious diseases. The invention comprises peptides, peptide fusions, pharmaceutical compositions, and methods for using these compounds and compositions. Peptides of the invention include, but are not limited to SEQ ID NOs:4, 6, 8, 10, 12, 21, or 24, optionally fused to a cell-permeating moiety.