Glucosylceramide synthase inhibitors

Glucosylceramide synthase inhibitors

The invention relates to inhibitors of glucosylceramide synthase (GCS) of the Formula I: represented by the following structural formulaor a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storag...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Good, Andrew, Makino, Elina, Cheng, Seng H, Husson, Herve, Leonard, John, Celatka, Cassandra, Marshall, John, Beskrovnaya, Oxana, Scheule, Ronald K, Xiang, Yibin, Skerlj, Renato, Jancsics, Katherine, Cabrera-Salazar, Mario A, Natoli, Thomas, Bourque, Elyse, Zhao, Zhong, Hirth, Bradford, Metz, Markus
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to inhibitors of glucosylceramide synthase (GCS) of the Formula I: represented by the following structural formulaor a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.