Carbohydrate conjugates as delivery agents for oligonucleotides

The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below:The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

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Bibliographische Detailangaben
Hauptverfasser:	Manoharan, Muthiah, Nair, Jayaprakash K, Maier, Martin, Rajeev, Kallanthottathil G
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below:The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):