Navigating bronchial pathways

The present invention relates to navigating in bronchial pathways. In order to provide further improved navigation guidance, a sequence of 2D X-ray images of a region of interest of a bronchial structure with an intrathoracic device (visible in the X-ray images) inserted in a bronchial pathway is provided. The intrathoracic device is tracked in the 2D X-ray images and direction and magnitude of repetitory cardiovascular and respiratory induced motion is assessed based on the tracked intrathoracic device. The assessed motion is modelled and a navigation information indicative of a range of the modelled motion is generated. The navigation information is shown as a confidence reference (310), for example a rEBUS historical trajectory confidence reference, to a user operating the intrathoracic device. As an example, an augmented fluoroscopy 2D image (302) of a thorax region is registered and shown overlaid with segmentation (304) of the bronchial structure and target lesion (312). Further, a confidence reference (314) of the current position of the rEBUS catheter may also be shown.