Nonuniformity correction systems and methods of diffusion-weighted magnetic resonance images

A magnetic resonance (MR) imaging method of correcting nonuniformity in diffusion-weighted (DW) MR images of a subject is provided. The method includes applying a DW pulse sequence along a plurality of diffusion directions with one or more numbers of excitations (NEX), and acquiring a plurality of DW MR images of the subject along the plurality of diffusion directions with the one or more NEX. The method also includes deriving a reference image and a base image based on the plurality of DW MR images, generating a nonuniformity factor image based on the reference image and the base image, and combining the plurality of DW MR images into a combined image. The method also includes correcting nonuniformity of the combined image using the nonuniformity factor image, and outputting the corrected image.