Input/output interface security

Methods, computer program products, and systems are presented. The Methods, computer program products, and systems can include, for example: examining hardware device transmitted data received through an I/O interface port of a computer system; determining in dependence on the examining whether the hardware device transmitted data received through the I/O interface port of the computer system satisfies a criterion; and in response to determining that the hardware device transmitted data received through the I/O interface port of the computer system satisfies the criterion, initiating a security process for protecting the computer system.