Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same

Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same

The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same:wherein X, Z, R1 and R2 are as defined in the specification.The compound of Chemical Formula (1) or pharmaceutically acceptable salt...

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Bibliographische Detailangaben
Hauptverfasser: Jang, Young Koo, Kim, Ji Yeon, Cha, Soo Bong, Cho, Nahm Ryune, Min, Hye Kyung, Jung, Hyo Jun, Choi, Eun Ju, Lee, Ji Won, Han, Seung Nam, Chung, Jin Yong, Ham, Seung Mo, Maeng, Cheol Young, Lee, Ju Young, Shin, Yong Je, Kim, Yong Gil, Joung, Chan Mi, Park, Jong Sil, Ryu, Eun Ju, Park, Chun Eung
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same:wherein X, Z, R1 and R2 are as defined in the specification.The compound of Chemical Formula (1) or pharmaceutically acceptable salt thereof acts as a positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5), thereby being useful in the prevention or treatment of disorder mediated by glutamate dysfunction and mGluR5.