Methods and compositions comprising a KRasG12C inhibitor and a VEGF inhibitor for treating solid tumors

Methods and compositions comprising a KRasG12C inhibitor and a VEGF inhibitor for treating solid tumors

Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. Compound 1 or a pharmaceutically acceptable salt thereof) and a VEGF antagonist (e.g., bevacizumab) and methods of using such combination therapies.

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Bibliographische Detailangaben
Hauptverfasser: Merchant, Mark Andrew, Lutzker, Stuart G, Lin, Ting-Kun Mark, Joo, Stephanie Royer, Evangelista, Marie, Mandlekar, Sandhya Vinayak, Schutzman, Jennifer Lee
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. Compound 1 or a pharmaceutically acceptable salt thereof) and a VEGF antagonist (e.g., bevacizumab) and methods of using such combination therapies.