Optical coherence tomography (OCT) system and method that measure stimulus-evoked neural activity and hemodynamic responses

A multi-modal functional OCT imaging methodology and system are provided that enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. An OCT angiography (OCTA)-guided IOS analysis is used to separate neural-IOS an...

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Bibliographische Detailangaben
Hauptverfasser: Son, Tae Yun, Yao, Xincheng
Format: Patent
Sprache:eng
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Zusammenfassung:A multi-modal functional OCT imaging methodology and system are provided that enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. An OCT angiography (OCTA)-guided IOS analysis is used to separate neural-IOS and hemodynamic-IOS changes in the same retinal image sequence. The OCTA-guided IOS data processing used for this purpose differentiates two functional images, namely, a neural-IOS map and a hemodynamic-IOS map, from the same image dataset.