Automated causal analysis of issues affecting workloads executing in an information technology infrastructure

An apparatus comprises a processing device configured to obtain workload traces characterizing resource execution metrics associated with workloads executing in an information technology infrastructure and to generate sets of workload causality profiles characterizing relationships between the resource execution metrics, the sets of workload causality profiles comprising first and at least second sets of workload causality profiles generated using first and at least second different types of models. The processing device is also configured to determine sets of causal topics comprising recurring patterns of the relationships between different ones of the resource execution metrics found in each of the sets of workload causality profiles. The processing device is further configured to identify clusters of causal topics each comprising at least one causal topic that is part of the first and second sets of causal topics, and to perform diagnosis of issues affecting the workloads based on the identified clusters.