System for single-molecule isolation for cell populations and single cells, and methods and uses thereof

The invention relates to the systems and methods for isolating single cells, capturing selected prey biomolecules within said cells, and detecting said prey biomolecules using a sensitive assay method. Also described herein are functionalized substrates and compositions for enabling the low limit of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Huang, Pingbo, Zhao, Qirui
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to the systems and methods for isolating single cells, capturing selected prey biomolecules within said cells, and detecting said prey biomolecules using a sensitive assay method. Also described herein are functionalized substrates and compositions for enabling the low limit of detection of selected prey biomolecules of selected cells.