Two-part nitric oxide generating topical compositions

A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor a...

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Bibliographische Detailangaben
Hauptverfasser:	Doverspike, Joshua C, Wu, Jianfeng, Meyerhoff, Mark E, Phan, James, Zhou, Yang, Xi, Chuanwu, Qin, Yu
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.