Method and device for continuously synthesizing cyclopropane compounds

The present disclosure discloses a method and a device for continuously synthesizing cyclopropane compounds. The method includes the following steps: continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a...

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Bibliographische Detailangaben
Hauptverfasser: Feng, Xichun, Hong, Hao, Lu, Jiangping, Zhang, Feng, Sun, Xingfang
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present disclosure discloses a method and a device for continuously synthesizing cyclopropane compounds. The method includes the following steps: continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a separator for stratification, the organic phase obtained by stratification overflowing into a second reactor, continuously consuming the diazomethane precursor in a second reactor to prepare diazomethane and performing an electron-rich monoolefin cyclopropanation reaction in situ so as to obtain the cyclopropane compound.