Processes and systems for producing and/or purifying gallium-68

The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The p...

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Bibliographische Detailangaben
Hauptverfasser:	Alnahwi, Aiman H, Tremblay, Sebastien, Ait-Mohand, Samia, Guerin, Brigitte
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CONVERSION OF CHEMICAL ELEMENTS DIAGNOSIS HUMAN NECESSITIES HYGIENE IDENTIFICATION MEDICAL OR VETERINARY SCIENCE NUCLEAR ENGINEERING NUCLEAR PHYSICS PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RADIOACTIVE SOURCES SURGERY THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.