Stable liquid formula comprising anti-TNFa antibody, acetate buffer, and glycine

Stable liquid formula comprising anti-TNFa antibody, acetate buffer, and glycine

Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is sti...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Su Jung, Oh, Jun Seok, Kim, Kwang Woo, Shin, Yeon Kyeong, Kang, Hye Young, Han, Won Yong, Lee, Joon Won, Kim, So Young
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.