Anti-PD-L1 and IL-2 cytokines

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Arkinstall, Stephen John, Germaschewski, Volker, Gillies, Stephen Douglas, Kirby, Ian, Gallagher, Thomas, Deantonio, Cecilia, Van Krinks, Cassandra, Campbell, Jamie, Sandy, Nikole, Kosmac, Miha
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.