Arylamide derivative having antitumor activity

Arylamide derivative having antitumor activity

The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt:wherein X1, X2, X3 and X4 are each independently -CR2═ or N═, R2 is, for example, a haloge...

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Bibliographische Detailangaben
Hauptverfasser: Hada, Kihito, Hattori, Kazuo, Hyodo, Ikumi, Kawasaki, Kenichi, Watanabe, Fumio, Aoki, Toshihiro, Tomizawa, Masaki, Isshiki, Yoshiaki
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt:wherein X1, X2, X3 and X4 are each independently -CR2═ or N═, R2 is, for example, a halogen atom, R1 is, for example, -S(═O)2-NH-R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.