Substituted amino acids as integrin inhibitors

Substituted amino acids as integrin inhibitors

The invention relates to compounds of formula (I):or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ1 integrin and αvβ6 integrin that are useful for treating fibrosis suc...

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Bibliographische Detailangaben
Hauptverfasser: Bailey, Christopher, Zheng, Yajun, Reilly, Maureen, Leftheris, Katerina, Morgans, Jr., David J, Finkelstein, Darren, Hom, Timothy, Cooper, Nicole, Muñoz, Manuel, Cha, Jacob
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to compounds of formula (I):or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ1 integrin and αvβ6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).