Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compo...

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Bibliographische Detailangaben
Hauptverfasser:	Broeker, Joachim, Gollner, Andreas, Hodges, Tim, Waterson, Alex, Smethurst, Christian Alan Paul, Cui, Jianwen, Karolyi-Oezguer, Jale, Little, Andrew, Abbott, Jason, Mantoulidis, Andreas, Sarkar, Dhruba, Fesik, Steve W, Treu, Matthias, Phan, Jason, Sun, Qi
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.