Information handling system and peripheral group wakeup radio interface synchronized communications

An information handling system wirelessly interfaces with plural peripheral devices, such as a keyboard or mouse, through primary radios that have a communication protocol, such as Bluetooth Low Energy or a wireless local area network. Secondary radios interface with their associated primary radio to provide a low power wake and sleep using wake and sleep signals sent between the secondary radios. An individual wake command is transmitted by a secondary radio to wake one peripheral or information handling system. A group wake command is transmitted by a secondary radio to wake plural peripherals and/or information handling system.