Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen

Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to...

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Bibliographische Detailangaben
Hauptverfasser: Whitehouse, Jonathon, McLaughlin, Rosaleen, Howes, Simon Andrew Martyn, Wheadon, Craig, Parker, Adam
Format: Patent
Sprache:eng
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Zusammenfassung:Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated Ibuprofen and to minimize aeration of Ibuprofen when mixed into suspension.