Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

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Bibliographische Detailangaben
Hauptverfasser:	Barczak, Nicholas, Han, Bingsong, Bair, Kenneth W, Zablocki, Mary-Margaret, Thomason, Jennifer R, Lancia, Jr., David R, Liu, Cuixian, Ng, Pui Yee, Rudnitskaya, Aleksandra, Martin, Matthew W, Zheng, Xiaozhang
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.