Shear stress sensitive liposomes

A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically rele...

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Bibliographische Detailangaben
Hauptverfasser: Saxer, Till, Müller, Bert, Tanasescu, Radu, Gerganova, Gabriela, Pfohl, Thomas, Zumbühl, Andreas, Müller, Dennis, Matviykiv, Sofiya, Neuhaus, Frederik, Buscema, Marzia
Format: Patent
Sprache:eng
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Zusammenfassung:A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.