Fibers comprising polyesteramide copolymers for drug deliver

The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV),whereinm+p varies from 0.9-0.1 and q varies from 0.1 to 0.9;m+p+q=1 whereby m or p could be 0;n is about 5 to about 300; (pref. 50-200);-R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, -(R9-CO-O-R10-O-CO-R9)-, -CHR11-O-CO-R12-COOCR11-, and combinations thereof;-R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, -(CH2)SH, -(CH2)2S(CH3), -CH2OH, -CH(OH)CH3, -(CH2)4NH3+, -(CH2)3NHC(═NH2+)NH2, -CH2COOH, -(CH2)COOH, -CH2-CO-NH2, -CH2CH-CO-NH2, -CH2CH2COOH, CH3-CH2-CH(CH3)-, (CH3)2-CH-CH2-, H2N-(CH2)4-, Ph-CH2, CH═C-CH2, HO-p-Ph-CH2, (CH3)2-CH-, Ph-NH-, NH-(CH2)3-C-, NH-CH═N-CH═C-CH2-;-R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol;-R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III);-R7 is selected from the group consisting of (C6-C10)aryl(C1-C6)alkyl;-R8 is -(CH2)4-;-R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene; and-R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.